"Not-so-identical" twins with trisomy 21 and perimembranous ventricular septal defects.
نویسندگان
چکیده
While trisomy 21 is a common genetic disorder in singletons, the incidence among identical twins is very rare, occurring in approximately 1-2 per 1000 twin gestations. Trisomy 21 is associated with high incidence of congenital heart defects, and commonly occurs with ventricular septal defects (VSDs). Physiologic burden of VSDs depends on prevalence of anatomic and other circulatory factors. A case of identical twins with trisomy 21 and large VSDs is described in the present report. Though genetically identical, phenotypes varied significantly. One twin was managed medically, while the other developed more significant heart failure, requiring operative repair.
منابع مشابه
Interrupted aortic arch in a child with trisomy 5q31.1q35.1 due to a maternal (20;5) balanced insertion.
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متن کاملPrenatal Isolated Ventricular Septal Defect May Not Be Associated with Trisomy 21
The aim of this study was to examine if isolated fetal ventricular septal defect (VSD) is associated with trisomy 21. One hundred twenty six cases with prenatal VSD diagnosed by a pediatric cardiologist were reviewed. Cases with known risk factors for congenital heart disease, the presence of other major anomalies, soft signs for trisomy 21 or a positive screen test for trisomy 21 were excluded...
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ورودعنوان ژورنال:
- Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
دوره 44 4 شماره
صفحات -
تاریخ انتشار 2016